Revised July 2017

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INSTRUCTIONS TO AUTHORS SCOPE Molecular and Cellular Biology® (MCB) is devoted to the ad- vancement and dissemination of fundamental knowledge con- cerning the molecular biology of all eukaryotic cells. MCB seeks technically rigorous, mechanistic studies that provide significant advances in the areas of gene expression and genome organiza- tion, cellular morphology and function, molecular metabolism, cellular trafficking, and signal transduction. The journal is also interested in studies that investigate molecular, cellular, and sys- temic host responses to pathogenic agents in chronic diseases and conditions. MCB is edited by leading investigators in the field of molec- ular biology, and decisions are based solely on scientific merit. MCB recognizes that rigorous, in-depth extensions of prior observations contribute in an important way to the advance- ment of scientific knowledge. We welcome studies that build upon, clarify, or question previous work and thereby move the field forward. Questions about these guidelines may be directed to the ed- itor in chief. If transfer to another ASM journal is recommended by an editor, the corresponding author will be contacted. Note that a manuscript rejected by one ASM journal on scientific grounds or on the basis of its general suitability for publication is considered rejected by all other ASM journals. EDITORIAL POLICY AND ETHICAL GUIDELINES As a member of the Committee on Publication Ethics (COPE), ASM adheres to COPE's Best Practice Guidelines and expects authors to observe the high standards of publication ethics set out by COPE. ASM requirements for submitted manuscripts are consis- tent with the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Jour- nals, as last updated by the International Committee of Medi- cal Journal Editors in December 2014 (http://www.icmje .org/). Authors are expected to adhere to the highest ethical stan- dards. The following sections of these Instructions include de- tailed information about ASM's ethical standards. Failure to comply with the policies described in these Instructions may result in a letter of reprimand, a suspension of publishing priv- ileges in ASM journals, and/or notification of the authors' in- stitutions. Authors employed by companies whose policies do not permit them to comply with ASM policies may be sanc- tioned as individuals and/or ASM may refuse to consider man- uscripts having authors from such companies. Use of Microbiological Information The Council Policy Committee (CPC) of the American So- ciety for Microbiology affirms the long-standing position of the Society that microbiologists will work for the proper and beneficent application of science and will call to the attention of the public or the appropriate authorities misuses of micro- biology or of information derived from microbiology. ASM members are obligated to discourage any use of microbiology contrary to the welfare of humankind, including the use of microbes as biological weapons. Bioterrorism violates the fun- damental principles expressed in the Code of Ethics of the So- ciety and is abhorrent to ASM and its members. ASM recognizes that there are valid concerns regarding the publication of information in scientific journals that could be put to inappropriate use as described in the CPC resolution mentioned above. Members of the ASM Journals Board will evaluate the rare manuscript that might raise such issues dur- ing the review process. However, as indicated elsewhere in these Instructions, primary-research articles must contain suf- ficient detail, and material/information must be made avail- able, to permit the work to be repeated by others. Supply of materials should be in accordance with laws and regulations gov- erning the shipment, transfer, possession, and use of biological materials and must be for legitimate, bona fide research needs. We ask that authors pay particular attention to the NSAR Select Agent/Toxin list on the CDC website /index.html and the U.S. Government Policy for Oversight of Life Sciences Dual Use Research of Concern (March 2012; http://www durc-032812.pdf). Use of Human Subjects or Animals in Research Authors of manuscripts describing research involving hu- man subjects or animal experimentation must obtain review and approval (or review and waiver) from their Institutional Review Board (IRB) or Institutional Animal Care and Use Committee (IACUC), as appropriate, prior to manuscript sub- mission. Authors of manuscripts that describe multisite re- search must obtain approval from each institution's IRB or IACUC, as appropriate. Documentation of IRB or IACUC status must be made available upon request. In the event that institutional review boards or committees do not exist, the authors must ensure that their research is carried out in accordance with the Declaration of Helsinki, as revised in 2013 ( /1760318). A statement of IRB or IACUC approval or waiver (and reason for waiver) or a statement of adherence to the Declaration of Helsinki must be included in the Materials and Methods section. Patient Identification Informed consent is not needed if the patient cannot be identified from any material in a manuscript. In the absence of informed consent, identifying details, such as patient initials, Copyright © 2017 American Society for Microbiology. All Rights Reserved. Instructions to Authors are updated throughout the year. The current version is available at July 2017, Instructions to Authors, pages 1–20 July 2017, Instructions to Authors 1 Molecular and Cellular Biology

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